Analysis of illegal peptide drugs via HILIC-DAD-MS
نویسندگان
چکیده
منابع مشابه
Hydrophilic Interaction Chromatography (HILIC) Separation of Basic Drugs using MS/MS Detection Application
The basic drugs, ranitidine and paroxetine were successfully separated using hydrophilic interaction liquid chromatography (HILIC). The elution order was reversed compared to reversed-phase liquid chromatography (RPLC). Good linearity was shown over the 0.5–100 ppb levels. A spiked serum was cleaned up by protein precipitation and an aliquot was directly injected into the HILIC/ESI-MS system. R...
متن کاملHydrophilic interaction chromatography (HILIC) for LC-MS/MS analysis of monoamine neurotransmitters.
BACKGROUND Hydrophilic interaction chromatography (HILIC) is becoming an increasingly popular alternative to traditional reversed-phase chromatography for the analysis of polar compounds. The ability to retain the most polar compounds in HILIC makes it attractive for the analysis of certain large groups of compounds, such as monoamines, which are inherently very polar. RESULTS This paper deta...
متن کاملDirect injection HILIC–MS/MS analysis of darunavir in rat plasma applying supported liquid extraction
A novel bioanalytical method was developed and validated for the quantitative determination of darunavir (DRV) in rat plasma by employing hydrophilic interaction chromatography and tandem mass spectrometry (HILIC-MS/MS) with supported liquid extraction (SLE). Irbesartan (IRB) was used as an internal standard (IS). The analyte in rat plasma (200 µL) was isolated through SLE using ethyl acetate a...
متن کاملCharacterization of nucleosides and nucleobases in natural Cordyceps by HILIC-ESI/TOF/MS and HILIC-ESI/MS.
A method combining hydrophilic interaction chromatography (HILIC) and electrospray ionization mass spectrometry (ESI-MS) was developed for the characterization and determination of natural Cordyceps. Separation was achieved on a Waters Xbridge Amide column with gradient elution. Identification of 15 target nucleosides and nucleobases was based on retention time, UV spectra and mass measurements...
متن کاملQualitative and Quantitative Analysis of Dan-Deng-Tong-Nao Capsules by HPLC-DAD-MS/MS
Dan-Deng-Tong-Nao capsules (DDTNCs), a traditional Chinese medicinal preparation consisting of Radix Salvia miltiorrhiza, Radix Pueraria lobata, Erigeron breviscapus, Rhizoma chuanxiong has been used for the treatment of apoplexy and the syndrome of apoplexy involving both collaterals and meridians caused by obstruction of collaterals by blood stasis in China. In this paper, a HPLC-DAD-MS/MS me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Talanta
سال: 2017
ISSN: 0039-9140
DOI: 10.1016/j.talanta.2017.06.034